BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (Middle Region) Peptide
BNIP3L
Reactivity: Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN973856
Quick Overview for BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (Middle Region) Peptide (ABIN973856)
Target
BNIP3L/NIX (BNIP3L)
(BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- CDSPSPQEDG QIMFDVEMHT SRDHSSQSEE EVVEGEKEVE ALKKSADWVS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Bnip3l Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))
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Background
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Bnip3l induces apoptosis. It interacts with viral and cellular anti-apoptosis proteins. It can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. It inhibits apoptosis induced by BNIP3. It is involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. Bnip3l may function as a tumor suppressor.
Alias Symbols: C86132, D14Ertd719e, Nip3L, Nix
Protein Size: 218 -
Molecular Weight
- 24 kDa
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Gene ID
- 12177
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NCBI Accession
- NM_009761, NP_033891
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UniProt
- Q9Z2F7
Target
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