Chromobox Homolog 3 (CBX3) Peptide
CBX3
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN974512
Quick Overview for Chromobox Homolog 3 (CBX3) Peptide (ABIN974512)
Target
CBX3
(Chromobox Homolog 3 (CBX3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CBX3 antibody (Catalog #: ARP34721_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CBX3 (Chromobox Homolog 3 (CBX3))
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Background
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At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. CBX3 binds DNA and is a component of heterochromatin. CBX3 also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of CBX3 may explain the association of heterochromatin with the inner nuclear membrane.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Alias Symbols: HECH, HP1-GAMMA, HP1Hs-gamma
Protein Interaction Partner: DNMT3B,DSN1,MIS12,MKI67,ATXN7L2,CBX1,CBX3,CBX5,DSN1,HIST1H1E,HIST3H3,L3MBTL,LBR,MIS12,MKI67,PIM1,SP100,TAF4,TRIM24,TRIM28,ARL5A,BAP1,CBX1,CBX3,CBX5,DSN1,E2F6,KDM5C,L3MBTL,L3MBTL2,LBR,MIS12,MKI67,PCGF6,PIM1,RING1,SP100,TRIM28,YAF2
Protein Size: 183 -
Molecular Weight
- 21 kDa
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Gene ID
- 11335
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NCBI Accession
- NM_016587, NP_057671
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UniProt
- Q13185
Target
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