Cyclin D1 (CCND1) (Middle Region) Peptide
CCND1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974599
Quick Overview for Cyclin D1 (CCND1) (Middle Region) Peptide (ABIN974599)
Target
Cyclin D1 (CCND1)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CCND1 antibody (Catalog #: AVARP03037_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Cyclin D1 (CCND1)
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Background
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CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BCL1, D11S287E, PRAD1, U21B31
Protein Interaction Partner: CHUK,CREBBP,CTNNB1,ERCC3,ESR1,NCOA3,POLR2A,RELA,BRCA1,CDK4,CDK4,CDK6,CDKN1A,CDKN1A,CDKN1A,CDKN1B,KLF6,PIN1,RB1,TAF1,FOXO4,AKAP8,AR,BRCA1,CALM1,CCNDBP1,CDK4,CDK6,CDKN1A,CDKN1B,CTNNB1,CUL3,DMTF1,EP300,ESR1,GSK3B,HDAC3,HERC5,IFI27,INSM1,KAT2B,MCM10,MYBL2,NCOA1,NCOA3,NPDC1,ORC4L,PCNA,PRKACA,RB1,RBL1,RBL2,RBX1,RFC1,RUNX1,SP1,STAT3,TAF1,THRA,THRB,TSC2,CREB1,EGFR,STAT3,AKAP8,AR,BRCA1,CCNDBP1,CDK4,CDK6,CDKN1A,CDKN1B,CDKN1C,CDKN2A,EP300,ESR1,HDAC3,HERC5,KAT2B,Mybl2,NCOA1,NCOA3,NEUROD1,NPDC1,PCNA,RB1,RBX1,RFC1,STAT3,TAF1,THRA,THRB,TSC2,XPO1
Protein Size: 295 -
Molecular Weight
- 34 kDa
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Gene ID
- 595
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NCBI Accession
- NM_053056, NP_444284
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UniProt
- P24385
Target
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