CD274 (PD-L1) (C-Term) Peptide
PD-L1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974661
Quick Overview for CD274 (PD-L1) (C-Term) Peptide (ABIN974661)
Target
PD-L1
(CD274 (PD-L1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- ELIRDYNSSR EDSLQDAWDY VQAQVKCCGW VSFYNWTDNA ELMNRPEVTY
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CD82 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PD-L1 (CD274 (PD-L1))
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Background
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This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27
Protein Interaction Partner: BCL3,CTNNB1,KAT5,MAP3K1,NCOR1,NFKB1,POLR2A,RUVBL1,RUVBL2,TAB2,CANX,CD19,CD4,CD63,EGFR,ERBB2,ERBB3,HBEGF,HLA-DMA,HLA-DMB,HLA-DRA,IGSF8,ITGA3,ITGA4,ITGA6,ITGB1,ITGB2,LRP1,NUP88,PTGFRN,VANGL1,CD151,CD19,CD4,CD46,CD63,CD9,EGFR,ERBB2,ERBB3,HBEGF,HLA-DMB,HLA-DO
Protein Size: 242 -
Molecular Weight
- 27 kDa
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Gene ID
- 3732
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NCBI Accession
- NM_001024844
Target
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