Charged Multivesicular Body Protein 4B (CHMP4B) (Middle Region) Peptide
CHMP4B
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974931
$160.46
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100 μg
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Quick Overview for Charged Multivesicular Body Protein 4B (CHMP4B) (Middle Region) Peptide (ABIN974931)
Target
CHMP4B
(Charged Multivesicular Body Protein 4B (CHMP4B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- EEISTAISKP VGFGEEFDED ELMAELEELE QEELDKNLLE ISGPETVPLP
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CHMP4B Antibody(ARP53340_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
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Background
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This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
Alias Symbols: C20orf178, CHMP4A, CTPP3, SNF7, SNF7-2, Shax1, dJ553F4.4, VPS32B, Vps32-2
Protein Interaction Partner: PDCD6IP,CHMP1B,CHMP4A,CHMP4B,CHMP4C,CHMP5,CHMP6,EXOSC9,HIPK2,PDCD6IP,PIAS2,STAMBP,UBE2I,VPS24,VPS4A,UBE2I
Protein Size: 224 -
Molecular Weight
- 25 kDa
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Gene ID
- 128866
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NCBI Accession
- NM_176812, NP_789782
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UniProt
- Q9H444
Target
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