Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP) (C-Term) Peptide
CILP
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974989
$160.46
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100 μg
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United States
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Quick Overview for Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP) (C-Term) Peptide (ABIN974989)
Target
CILP
(Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- YIKVKIVGPL EVNVRSRNMG GTHRQTVGKL YGIRDVRSTR DRDQPNVSAA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CILP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP) peptide
CILP Reactivity: Human, Rat, Dog, Mouse Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))
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Background
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Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins, an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.
Alias Symbols: CILP-1, HsT18872
Protein Size: 1184 -
Molecular Weight
- 52 kDa
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Gene ID
- 8483
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NCBI Accession
- NM_003613, NP_003604
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UniProt
- O75339
Target
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