Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1) Peptide
CSH1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN975362
Quick Overview for Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1) Peptide (ABIN975362)
Target
CSH1
(Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CSH1 antibody (Catalog #: ARP40350_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))
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Background
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CSH1 is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
Alias Symbols: PL, CSA, CS-1, CSMT, hCS-A
Protein Interaction Partner: PRLR,PTPN12,SMAD2,SMAD4,SMAD9,POLR2A,SMAD3
Protein Size: 217 -
Molecular Weight
- 24 kDa
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Gene ID
- 1442
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NCBI Accession
- NM_001317, NP_001308
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UniProt
- P01243
Target
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