Casein Kinase 1, epsilon (CSNK1E) (N-Term) Peptide
CSNK1E
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975370
Quick Overview for Casein Kinase 1, epsilon (CSNK1E) (N-Term) Peptide (ABIN975370)
Target
CK1 epsilon (CSNK1E)
(Casein Kinase 1, epsilon (CSNK1E))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CSNK1E antibody (Catalog #: ARP51987_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Casein Kinase 1, epsilon (CSNK1E) peptide
CSNK1E Reactivity: Human, Mouse, Rat, Dog Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))
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Background
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Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. CSNK1E can phosphorylate a large number of proteins. CSNK1E participates in Wnt signaling and is the central component of the circadian clock. It may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. CSNK1E inhibits cytokine-induced granuloytic differentiation.The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: HCKIE, MGC10398, CKIepsilon
Protein Interaction Partner: ESR1,AKAP9,ANKRD6,APC,ARNTL,AXIN1,AXIN2,BID,CRY1,CSNK1E,DVL1,DVL2,DVL3,OCLN,PER1,PER2,PER3,PPP1R14A,RAD54B,SOCS3,ANKRD6,ARNTL,AXIN1,Cry1,DVL1,DVL2,MCC,PER1,PER3,RAD54B,Trp53
Protein Size: 416 -
Molecular Weight
- 47 kDa
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Gene ID
- 1454
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NCBI Accession
- NM_001894, NP_001885
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UniProt
- P49674
Target
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