DCP2 Decapping Enzyme Homolog (DCP2) Peptide
DCP2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975632
Quick Overview for DCP2 Decapping Enzyme Homolog (DCP2) Peptide (ABIN975632)
Target
DCP2
(DCP2 Decapping Enzyme Homolog (DCP2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-DCP2 antibody (Catalog #: ARP41150_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DCP2 (DCP2 Decapping Enzyme Homolog (DCP2))
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Background
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DCP2 is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. DCP2 removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. It has higher activity towards mRNAs that lack a poly(A) tail, but has no activity towards a cap structure lacking a RNA moiety.DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-539 AY135173.1 1-539 540-1992 AK090564.1 481-1933 1993-8947 AC008536.7 154323-161277
Alias Symbols: FLJ33245, NUDT20
Protein Interaction Partner: EIF2C1,EIF2C2,DCP1A,DCP1B,DCP2,EIF2C1,EIF2C2,NAGK,POLA2,PSMB1,UPF1,UPF2,DCP1A,PSMB1,UPF1,UPF2,UPF3A
Protein Size: 420 -
Molecular Weight
- 48 kDa
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Gene ID
- 167227
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NCBI Accession
- NM_152624, NP_689837
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UniProt
- Q8IU60
Target
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