Dynactin 2 (p50) (DCTN2) (N-Term) Peptide
DCTN2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975637
$160.46
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100 μg
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Quick Overview for Dynactin 2 (p50) (DCTN2) (N-Term) Peptide (ABIN975637)
Target
Dynamitin (DCTN2)
(Dynactin 2 (p50) (DCTN2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-DCTN2 antibody (Catalog #: ARP58450_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))
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Background
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DCTN2 is a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DCTN50, DYNAMITIN, RBP50
Protein Interaction Partner: DCTN1,BICD1,BICD2,GADD45A,GNAO1,GOLM1,GSK3B,MARCKSL1,RPGR,ZW10,BICD2,CALM1,GADD45A,GNAO1,GOLM1,HGS,MARCKSL1,PAFAH1B1
Protein Size: 406 -
Molecular Weight
- 45 kDa
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Gene ID
- 10540
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NCBI Accession
- NM_006400, NP_006391
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UniProt
- Q13561
Target
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