Dickkopf 2 Homolog (DKK2) (C-Term) Peptide
DKK2
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN975818
Quick Overview for Dickkopf 2 Homolog (DKK2) (C-Term) Peptide (ABIN975818)
Target
DKK2
(Dickkopf 2 Homolog (DKK2))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- RTSDCGPGLC CARHFWTKIC KPVLREGQVC SRRGHKDTAQ APEIFQRCDC
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Dkk4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Dickkopf 2 Homolog (DKK2) peptide
DKK2 Reactivity: Human, Mouse, Cow, Dog, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DKK2 (Dickkopf 2 Homolog (DKK2))
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Background
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Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Alias Symbols: Dkk-4, MGC25705
Protein Size: 221 -
Molecular Weight
- 24 kDa
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Gene ID
- 234130
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NCBI Accession
- NM_145592, NP_663567
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UniProt
- Q8VEJ3
Target
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