DNA Methyltransferase 1-Associated Protein 1 (DMAP1) Peptide
DMAP1
Reactivity: Human
Host: Synthetic
BP, WB
Quick Overview for DNA Methyltransferase 1-Associated Protein 1 (DMAP1) Peptide (ABIN975858)
Target
DMAP1
(DNA Methyltransferase 1-Associated Protein 1 (DMAP1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-DMAP1 antibody (Catalog #: ARP32917_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))
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Background
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DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Alias Symbols: EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1
Protein Interaction Partner: DNMT1,RGS6,C19orf2,C20orf20,DAXX,DNMT1,HDAC2,ING1,RGS6,TOMM34,TSG101,C19orf2,DNMT1,ING1,ING3,RGS6,RUVBL1,RUVBL2,TSG101
Protein Size: 467 -
Molecular Weight
- 51 kDa
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Gene ID
- 55929
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NCBI Accession
- NM_001034024, NP_001029196
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UniProt
- Q9NPF5
Target
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