Deleted in Malignant Brain Tumors 1 (DMBT1) (N-Term) Peptide
DMBT1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975861
$160.46
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100 μg
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Quick Overview for Deleted in Malignant Brain Tumors 1 (DMBT1) (N-Term) Peptide (ABIN975861)
Target
DMBT1
(Deleted in Malignant Brain Tumors 1 (DMBT1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- SWSTPSPDTL PTITLPASTV GSESSLALRL VNGGDRCQGR VEVLYRGSWG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-DMBT1 Antibody(ARP42352_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))
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Background
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Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.
Alias Symbols: GP340, MGC164738, muclin
Protein Interaction Partner: SFTPA1,SFTPD,SFTPA1,SFTPD
Protein Size: 2413 -
Molecular Weight
- 258 kDa
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Gene ID
- 1755
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NCBI Accession
- NM_007329, NP_015568
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UniProt
- Q9UGM3
Target
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