Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (Middle Region) Peptide
DMTF1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975884
Quick Overview for Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (Middle Region) Peptide (ABIN975884)
Target
DMP1 (DMTF1)
(Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-DMTF1 antibody (Catalog #: ARP34828_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) peptide
DMTF1 Reactivity: Human Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
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Background
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DMTF1 is a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. DMTF1 is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of DMTF1 is regulated by binding of D-cyclins. The gene encoding DMTF1 is hemizygously deleted in approximately 40 % of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer.
Alias Symbols: DMP1, DMTF, FLJ41265, hDMP1
Protein Interaction Partner: ATF7IP,CCND1,CCND2,CCND3
Protein Size: 760 -
Molecular Weight
- 84 kDa
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Gene ID
- 9988
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NCBI Accession
- NM_021145, NP_066968
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UniProt
- Q9Y222
Target
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