Deltex Homolog 2 (DTX2) Peptide
DTX2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976019
Quick Overview for Deltex Homolog 2 (DTX2) Peptide (ABIN976019)
Target
DTX2
(Deltex Homolog 2 (DTX2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-DTX2 antibody (Catalog #: ARP43285_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DTX2 (Deltex Homolog 2 (DTX2))
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Background
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DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Alias Symbols: KIAA1528, MGC71098, RNF58
Protein Interaction Partner: DTX1,DTX2,DTX3,HPCAL1,HPCAL4,NCALD,NCS1,NOTCH1,PLSCR1,RBPMS,RFX6,RHOXF2,TRIP13,UBE2D4,UBQLN4,VSNL1,HPCAL1,HPCAL4,NCALD,NCS1,PLSCR1,RBPMS,RFX6,RHOXF2,SFN,TRIP13,UBE2D4,VSNL1
Protein Size: 575 -
Molecular Weight
- 62 kDa
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Gene ID
- 113878
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NCBI Accession
- NM_001102596, NP_001096066
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UniProt
- Q6XM87
Target
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