Dual Specificity Phosphatase 5 (DUSP5) (Middle Region) Peptide
DUSP5
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976033
Quick Overview for Dual Specificity Phosphatase 5 (DUSP5) (Middle Region) Peptide (ABIN976033)
Target
DUSP5
(Dual Specificity Phosphatase 5 (DUSP5))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- AGSSLIGHLQ TLSPDMQGAY CTFPASVLAP VPTHSTVSEL SRSPVATATS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-DUSP5 Antibody(ARP58225_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DUSP5 (Dual Specificity Phosphatase 5 (DUSP5))
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Background
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The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.
Alias Symbols: DUSP, HVH3
Protein Interaction Partner: MAPK1,MAPK3,MAPK3
Protein Size: 384 -
Molecular Weight
- 42 kDa
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Gene ID
- 1847
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NCBI Accession
- NM_004419, NP_004410
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UniProt
- Q16690
Target
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