Dynein, Light Chain, LC8-Type 1 (DYNLL1) (Middle Region) Peptide
DYNLL1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976055
Quick Overview for Dynein, Light Chain, LC8-Type 1 (DYNLL1) (Middle Region) Peptide (ABIN976055)
Target
DYNLL1
(Dynein, Light Chain, LC8-Type 1 (DYNLL1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- NIEKDIAAHI KKEFDKKYNP TWHCIVGRNF GSYVTHETKH FIYFYLGQVA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-DYNLL1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))
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Background
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Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.
Alias Symbols: DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, MGC126137, MGC126138, PIN, hdlc1
Protein Interaction Partner: BCAS1,DLGAP1,DLGAP1,DYNLL1,MYO5A,NFKBIA,PAN2,PKIA,PKIB,PKIG,SLC25A10,ACTB,ACTC1,ACTG1,ALDOA,BCAS1,BCL2L11,C14orf1,CA2,CACNB1,CLIP2,CS,DAZ1,DLG4,DLGAP1,DNAJB9,DNM2,DNM3,DNMT1,DYNC1H1,DYNC1I1,DYNLL1,EEF1A1,GAPDH,GLUD1,GLUL,GPHN,GRIN3A,HIP1R,HSPA8,LDHA,MAP1B
Protein Size: 89 -
Molecular Weight
- 10 kDa
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Gene ID
- 8655
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NCBI Accession
- NM_001037494, NP_001032583
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UniProt
- P63167
Target
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