E2F3 Peptide
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976080
Quick Overview for E2F3 Peptide (ABIN976080)
Target
E2F3
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-E2F3 antibody (Catalog #: ARP38089_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- E2F3
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Background
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E2F3 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. E2F3 binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.
Alias Symbols: E2F-3
Protein Interaction Partner: BIRC5,CDC25A,CDC6,CDK1,EAPP,FHL2,GAB2,JMY,MSH2,MT1G,MYBL2,PPP1R13B,RYBP,TP53BP2,TP53INP1,UXT,CCNA2,CDK3,RB1,RYBP,SP1,TFDP1,TFDP2,TFE3,YY1,CREBBP,FHL2,MGA,MYBL2,PKIB,RNF144A,RYBP,SPIB,Sp1,TEAD3,TFE3,WNK1
Protein Size: 334 -
Molecular Weight
- 37 kDa
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Gene ID
- 1871
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NCBI Accession
- NM_001243076
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UniProt
- Q68DT0
Target
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