E2F Transcription Factor 4, P107/p130-Binding (E2F4) Peptide
E2F4
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN976081
Quick Overview for E2F Transcription Factor 4, P107/p130-Binding (E2F4) Peptide (ABIN976081)
Target
E2F4
(E2F Transcription Factor 4, P107/p130-Binding (E2F4))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-E2F4 antibody (Catalog #: ARP31175_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))
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Background
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The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins. It is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It also plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Alias Symbols: E2F-4
Protein Interaction Partner: ACR,ARHGAP11A,BARD1,BIRC5,BRCA1,BTRC,C21orf32,CBX5,CCDC76,CCNA2,CCNA2,CDC25A,CDC6,CDK1,CDK1,CDK1,CHEK1,CSDA,CSTF3,CYP27B1,DBF4B,E2F1,E2F2,FHL2,FLJ20712,GAS2L1,HIST1H2AG,HIST1H2BJ,HIST2H4A,HOXA3,JMY,JPH2,LMO7,MAD2L1,MAP3K7,METAP2,MFAP1,MGC45922,MLH1,MSH2,MT1G,MYBL2,MYC,PBK,PPIA,PPP1R13B,PRR11,PSMA4,QPCTL,RAD51,RAD54L,RAD54L,RBL1,RBL1,RBL2,RECQL,SLC3A2,SNRPD2,SOAT2,SRC,TFDP1,TOP2A,TP53BP2,TP53INP1,TRIM55,TTK,TYMS,UXT,tat,ARID3A,BRCA1,NDN,NOLC1,RB1,RBL1,RBL2,SMAD2,SMAD3,TFDP1,TFDP2,TRRAP,BRCA1,CCNE1,FHL2,HDAC1,MGA,Ndn,RB1,RBL1,RNF144A,RYBP,SMAD3,SPIB,TFDP1,TFDP2
Protein Size: 413 -
Molecular Weight
- 44 kDa
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Gene ID
- 1874
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NCBI Accession
- NM_001950, NP_001941
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UniProt
- Q16254
Target
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