Endothelin 3 (EDN3) (C-Term) Peptide
EDN3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976136
Quick Overview for Endothelin 3 (EDN3) (C-Term) Peptide (ABIN976136)
Target
Endothelin 3 (EDN3)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- LHFCTQTLDV SSNSRTAEKT DKEEEGKVRG ANRGLCQRRL KSRTNKASRL
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-EDN3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Endothelin 3 (EDN3)
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Background
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The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Alias Symbols: ET3, MGC15067, MGC61498, ET-3, WS4B, HSCR4, PPET3
Protein Interaction Partner: CMA1,CTSE,EDNRA,EDNRB,KEL
Protein Size: 219 -
Molecular Weight
- 24 kDa
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Gene ID
- 1908
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NCBI Accession
- NM_207032, NP_996915
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UniProt
- P14138
Target
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