Estrogen Receptor 1 (ESR1) (Middle Region) Peptide
ESR1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976441
Quick Overview for Estrogen Receptor 1 (ESR1) (Middle Region) Peptide (ABIN976441)
Target
Estrogen Receptor alpha (ESR1)
(Estrogen Receptor 1 (ESR1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ESR1 antibody (Catalog #: ARP45592_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
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Background
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Hairy/enhancer of split-related proteins, such as HEY1, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
Alias Symbols: DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1
Protein Interaction Partner: ANP32A,AXIN2,BCAS2,BLOC1S1,CCND1,CHUK,CTNNB1,DDX17,DDX5,EBAG9,EIF3I,EP300,ESR2,HDAC1,JUN,JUNB,KDM5A,MED1,MPG,MYC,NCOA1,NCOA2,NCOA3,NCOA3,NCOR1,NCOR2,NRIP1,PGR,PGR,PHB2,PRMT2,RBM23,STAT5A,TFF1,TFF1,TP53,TRIM24,TRRAP,AP1B1,ASCC2,BAGE3,C21orf129,CELSR1,CSNK1E,CYB5R3,DSCAM,FHL2,LOC441967,NCAM2,NRIP1,PIAS1,SFI1,SLC37A1,SNAP29,SOD1,TFF1,TFF1,THOC5,UBE2I,XBP1,AHR,AKAP13,AKT1,AKT2,AR,ARHGEF15,ARNT,BAG1,BCAR1,BCAS2,BDNF,BRCA1,CALM1,CALM3,CALM3,CAV1,CCND1,CCNH,CCNT1,CDC25B,CDK7,CEBPB,CHD9,CHUK,CITED1,COBRA1,COPS5,CREBBP,CSNK2B,CTNNB1,CUEDC2,CUL4B,DDX5,DDX54,DNTTIP2,DUT,EGFR,EIF3I,EP300,ERBB2,ESR1,ESR2,ESRRA,FHL2,FLII,FOXO1,FOXO3,FOXO4,GADD45B,GADD45G,GNAI1,GRB2,GTF2B,GTF2H1,HEXIM1,HNF4A,HSP90AA1,HSP90AB1,HSPA4,IGF1R,ISL1,ITGB3BP,JUN,JUNB,JUND,KAT5,KDM5A,KIF1A,LCK,LOH3CR2A,MAPK1,MAPK14,MAPK3,MDM2,MED1,MED24,MKNK2,MLL2,MMS19,MNAT1,MPG,MTA1,MTCH2,MVP,NCOA1,NCOA2,NCOA3,NCOA6,NCOA7,NCOR1,NCOR2,NFKB1,NPPA,NR0B1,NR0B2,NR1H4,NR2C1,NR2C2,NR2F1,NR2F6,NRIP1,NSD1,PAK1,PAK6,PELP1,PGR,PHB2,PIAS1,PIAS3,PIK3R1,PIK3R3,PNRC2,POLR1B,POLR2D,POU2F1,POU4F1,POU4F2,PPARGC1A,PPARGC1B,PRDM2,PRKACA,PRMT1,PRMT2,PSMC5,PTGES3,PTPN1,PTPN6,RARA,RBM23,RBM39,RBM9,RELA,REXO4,RFX4,RGS3,RNF14,RNF4,RPS6KA1,RPS6KA3,RXRA,SAFB,SAFB2,SHC1,SLC30A9,SMAD2,SMAD3,SMAD4,SMARCA2,SMARCA4,SMARCD3,SMARCE1,SOS1,SP1,SP3,SRC,SREBF1,STAT5A,STRN,STUB1,TAF10,TAP1,TBP,TCF20,TDG,THRA,THRB,TNFRSF14,TP53,TRIM24,TRIM28,TRIM59,TRIP4,TRRAP,TSC2,TUBA1B,TUBB,UBE2I,USF1,WIPI1,XBP1,YWHAH,ZBTB16,ZBTB17,ZNF398,AHR,AKAP13,BAG1,BAZ1B,BRCA1,CAV1,CCNC,CCND1,CCNH,CDC25B,CDK7,CDK8,CEBPA,CEBPB,COBRA1,CREBBP,CTNNB1,DAP3,DDX17,DDX5,DDX54,DNTTIP2,EP300,ESR1,ESR2,FKBP4,FKBP5,FOXO1,FOXO4,GADD45A,GADD45G,GTF2H1,Gadd45b,HSP90AA1,HSPA4,IGF1R,ISL1,JUN,KAT5,KDM5A,LDB1,MAPK1,MDM2,MED1,MED10,MED12,MED13,MED14,MED16,MED17,MED20,MED21,MED23,MED24,MED6,MED7,MGMT,MNAT1,MTA1,MVP,NCOA1,NCOA2,NCOA3,NCOA4,NCOA6,NCOA7,NCOR1,NGG1,NR0B2,NR2C1,NR2C2,NR2F1,NR2F6,NRIP1,Nr0b2,Nr1i2,Nsd1,PAK6,PDLIM1,PELP1,PHB2,PIAS2,PIK3R1,POU2F1,POU2F2,POU4F1,POU4F2,PPARGC1A,PPARGC1B,PPID,PRDM2,PRMT1,PRMT2,PTEN,PTGES3,PTMA,RBM39,RBM9,REXO4,RLIM,RNF4,SAFB,SAFB2,SHC1,SMAD2,SMARCA2,SMARCA4,SMARCD1,SMARCE1,SRA1,SRC,STAT3,STAT5A,SVIL,TADA3,TBP,TDG,TP53,TRAM1,TRIM24,TRIM25,TRIP4,TRRAP,Tada3,UBC,XBP1,YWHAQ,ZBTB16,ZNF398
Protein Size: 595 -
Molecular Weight
- 66 kDa
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Gene ID
- 2099
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NCBI Accession
- NM_000125, NP_000116
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UniProt
- P03372
Target
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