Fas (TNFRSF6)-Associated Via Death Domain (FADD) Peptide
FADD
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all FADD products
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-FADD antibody (Catalog #: AVARP01012_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
- Background
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The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
Alias Symbols: GIG3, MORT1
Protein Interaction Partner: CASP8,CASP8,CFLAR,CFLAR,FAS,FAS,NOL3,TRADD,TRADD,TRADD,ABCA1,ANK3,CASP10,CASP8,CASP8AP2,CFLAR,CSNK1A1,DAP3,DAPK1,DDX24,DEDD,EDA2R,FAF1,FAS,FASLG,HIPK3,IKBKG,IRAK1,LRDD,LRRCC1,MBD4,MOBKL3,MYD88,NACA,NOL3,PEA15,PRKCZ,PTPN13,RALBP1,RAP1A,RIPK1,RYBP,STAT1,TNFRSF10A,TNFRSF10B,TRADD,TRAF2,XPO5,ABCA1,ARHGDIA,BID,CASP10,CASP8,CASP8AP2,CFLAR,DAP3,DAPK1,DEDD,EZR,FAS,FASLG,HIPK3,LRDD,MAPK8,MBD4,MOBKL3,MSN,NACA,NOL3,PEA15,PRKCZ,RHOA,RIPK1,RYBP,SUMO1,TNFRSF10A,TNFRSF10B,TNFRSF1A,TRADD
Protein Size: 208 - Molecular Weight
- 23 kDa
- Gene ID
- 8772
- NCBI Accession
- NM_003824, NP_003815
- UniProt
- Q13158
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