Fibrillarin (FBL) Peptide
FBL
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all Fibrillarin (FBL) products
- Fibrillarin (FBL)
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-FBL antibody (Catalog #: ARP40366_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Fibrillarin (FBL)
- Background
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FBL is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. FBL contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.
Alias Symbols: FIB, FLRN, RNU3IP1
Protein Interaction Partner: SNORD3A,DDX17,DDX5,MAP3K14,PIN4,PRMT1,PSMB6,SMN2,SMN2,SNRPN,TBC1D17,ARRB2,BAK1,C1QBP,CD40,CDK2,DDX20,DDX5,DDX56,GEMIN4,MCRS1,MEPCE,NOP2,PASK,PIN4,PRMT1,PRMT5,RIOK3,RTCD1,SIP1,SMN1,TBC1D17,TUBA3C,TUBB1
Protein Size: 321 - Molecular Weight
- 35 kDa
- Gene ID
- 2091
- NCBI Accession
- NM_001436, NP_001427
- UniProt
- P22087
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