F-Box and WD Repeat Domain Containing 2 (FBXW2) (Middle Region) Peptide
FBXW2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976768
$160.46
Plus shipping costs $50.00
100 μg
Shipping to:
United States
Delivery in 11 to 17 Business Days
Quick Overview for F-Box and WD Repeat Domain Containing 2 (FBXW2) (Middle Region) Peptide (ABIN976768)
Target
FBXW2
(F-Box and WD Repeat Domain Containing 2 (FBXW2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- Middle Region
-
Characteristics
- This is a synthetic peptide designed for use in combination with anti-FBXW2 antibody (Catalog #: ARP43109_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
F-Box and WD Repeat Domain Containing 2 (FBXW2) peptide
FBXW2 Reactivity: Human, Mouse, Rat, Cow, Dog, Pig Host: Synthetic BP, Imm
-
-
Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handling Advice
- Avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- FBXW2 (F-Box and WD Repeat Domain Containing 2 (FBXW2))
-
Background
-
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. FBXW2 is the second identified member of the F-box family and contains multiple WD-40 repeats.F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
Alias Symbols: FBW2, Fwd2, MGC117371, Md6
Protein Interaction Partner: SKP1,SKP1,SKP1,CUL1,SKP1,CDC34,CUL1,SKP1,UBE2D2
Protein Size: 454 -
Molecular Weight
- 51 kDa
-
Gene ID
- 26190
-
NCBI Accession
- NM_012164, NP_036296
-
UniProt
- Q9UKT8
Target
-
You are here:
