F-Box and WD Repeat Domain Containing 7 (FBXW7) (Middle Region) Peptide
FBXW7
Reactivity: Mouse
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN976770
Quick Overview for F-Box and WD Repeat Domain Containing 7 (FBXW7) (Middle Region) Peptide (ABIN976770)
Target
FBXW7
(F-Box and WD Repeat Domain Containing 7 (FBXW7))
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- Middle Region
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Sequence
- GIDEPLHIKR RKIIKPGFIH SPWKSAYIRQ HRIDTNWRRG ELKSPKVLKG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Fbxw7 Antibody(ARP37443_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Background
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Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Alias Symbols: 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
Protein Interaction Partner: Jun,Npm1
Protein Size: 629 -
Molecular Weight
- 70 kDa
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Gene ID
- 50754
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NCBI Accession
- NM_080428, NP_536353
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UniProt
- Q8VBV4
Target
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