FYVE, RhoGEF and PH Domain Containing 1 (FGD1) Peptide
FGD1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN976822
Quick Overview for FYVE, RhoGEF and PH Domain Containing 1 (FGD1) Peptide (ABIN976822)
Target
FGD1
(FYVE, RhoGEF and PH Domain Containing 1 (FGD1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FGD1 antibody (Catalog #: ARP31673_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))
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Background
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FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.
Alias Symbols: AAS, FGDY, MRXS16, ZFYVE3
Protein Interaction Partner: ABP1,CDC42,CTTN,ELMO1,CDC42
Protein Size: 961 -
Molecular Weight
- 107 kDa
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Gene ID
- 2245
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NCBI Accession
- NM_004463, NP_004454
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UniProt
- P98174
Target
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