Frizzled Family Receptor 8 (FZD8) (N-Term) Peptide
FZD8
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977174
Quick Overview for Frizzled Family Receptor 8 (FZD8) (N-Term) Peptide (ABIN977174)
Target
FZD8
(Frizzled Family Receptor 8 (FZD8))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FZD8 antibody (Catalog #: ARP41283_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FZD8 (Frizzled Family Receptor 8 (FZD8))
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Background
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FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Alias Symbols: FZ-8, hFZ8
Protein Interaction Partner: RYK,WNT1,GOPC,LRP5,LRP6,RYK,WNT1,LRP5,LRP6,WNT1
Protein Size: 694 -
Molecular Weight
- 73 kDa
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Gene ID
- 8325
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NCBI Accession
- NM_031866, NP_114072
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UniProt
- Q9H461
Target
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