gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Peptide
GABRA1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977203
Quick Overview for gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Peptide (ABIN977203)
Target
GABRA1
(gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-GABRA1 antibody (Catalog #: ARP34977_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))
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Background
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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.
Alias Symbols: ECA4, EJM, EJM5
Protein Interaction Partner: PPP3CA,PRKCD,PRKCG,PRKCD,PRKCG
Protein Size: 456 -
Molecular Weight
- 52 kDa
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Gene ID
- 2554
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NCBI Accession
- NM_000806, NP_000797
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UniProt
- P14867
Target
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