Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) Peptide
GADD45B
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN977232
Quick Overview for Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) Peptide (ABIN977232)
Target
GADD45B
(Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-GADD45B antibody (Catalog #: ARP48346_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))
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Background
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The function of GADD45B is involved in the regulation of growth and apoptosis.This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DKFZP566B133, GADD45BETA, MYD118
Protein Interaction Partner: EGR1,CCNB1,CDK1,GADD45GIP1,PCNA,PCNA,CCNB1,CDK1,CDKN1A,ESR1,GADD45G,GADD45GIP1,MAP2K7,MAP3K4,MAP3K5,PCNA,PPARA,PPARD,PPARG,CCNB1,CDK1,GADD45A,GADD45GIP1,MAP2K7,MAP3K4,MAP3K5
Protein Size: 160 -
Molecular Weight
- 18 kDa
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Gene ID
- 4616
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NCBI Accession
- NM_015675, NP_056490
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UniProt
- O75293
Target
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