Glucokinase (Hexokinase 4) (GCK) (N-Term) Peptide
GCK
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GCK products
- GCK (Glucokinase (Hexokinase 4) (GCK))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RVMLVKVGEG EEGQWSVKTK HQMYSIPEDA MTGTAEMLFD YISECISDFL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GCK Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GCK (Glucokinase (Hexokinase 4) (GCK))
- Background
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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Alias Symbols: FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2, LGLK
Protein Interaction Partner: GCKR,INS,PFKFB2,GCKR,MIG1,PFKFB2
Protein Size: 464 - Molecular Weight
- 51 kDa
- Gene ID
- 2645
- NCBI Accession
- NM_033508, NP_277043
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