Growth Hormone Receptor (GHR) (N-Term) Peptide
GHR
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977395
Quick Overview for Growth Hormone Receptor (GHR) (N-Term) Peptide (ABIN977395)
Target
Growth Hormone Receptor (GHR)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-GHR antibody (Catalog #: ARP44230_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Growth Hormone Receptor (GHR)
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Background
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GHR is a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature.This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GHBP
Protein Interaction Partner: AP2A1,CISH,GH2,GHR,GRB10,GRB2,IRS1,JAK1,JAK2,NCOA6,PIK3R1,PRLR,PTPN11,PTPN2,PTPN6,SGTA,SHC1,SOCS1,SOCS2,SOCS3,STAT3,STAT5A,STAT5B,TYK2,BTRC,CISH,GH1,GRB10,GRB2,JAK1,JAK2,PIK3R1,PLCG1,PTPN11,SGTA,SHC1,SOCS1,SOCS2,SOCS3,STAT3,STAT5B,TYK2
Protein Size: 638 -
Molecular Weight
- 70 kDa
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Gene ID
- 2690
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NCBI Accession
- NM_000163, NP_000154
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UniProt
- P10912
Target
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