Gephyrin (GPHN) (N-Term) Peptide
GPHN
Reactivity: Human
Host: Synthetic
BP, WB
Quick Overview for Gephyrin (GPHN) (N-Term) Peptide (ABIN977588)
Target
Gephyrin (GPHN)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-GPHN antibody (Catalog #: ARP51838_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Gephyrin (GPHN)
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Background
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GPHN is a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described, however, the full-length nature of all transcript variants is not currently known. This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described, however, the full-length nature of all transcript variants is not currently known.
Alias Symbols: GEPH, GPH, GPHRYN, KIAA1385
Protein Interaction Partner: ARHGEF9,DYNLL1,DYNLL2,ENAH,GABARAP,GLRB,GPHN,MTOR,PFN1,PIN1,TUBA4A,ARHGEF9,GLRB,MTOR,Mtor,OTUD4,PFN1,PRPF4
Protein Size: 736 -
Molecular Weight
- 80 kDa
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Gene ID
- 10243
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NCBI Accession
- NM_001024218, NP_001019389
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UniProt
- Q9NQX3
Target
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