GRB2-Related Adaptor Protein (GRAP) (Middle Region) Peptide
GRAP
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all GRAP products
- GRAP (GRB2-Related Adaptor Protein (GRAP))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KRQIFLRDEE PLLKSPGACF AQAQFDFSAQ DPSQLSFRRG DIIEVLERPD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-GRAP Antibody(ARP52210_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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GRB2-Related Adaptor Protein (GRAP) peptide
GRAP Reactivity: Human, Rat, Cow, Mouse Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- GRAP (GRB2-Related Adaptor Protein (GRAP))
- Background
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This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.
Alias Symbols: MGC64880
Protein Interaction Partner: ARHGAP32,ARHGAP32,EPOR,FASLG,FYN,KHDRBS1,KIT,LAT,LCK,PLCG1,SHC1,SOS1,EPOR,FASLG,GAB2,KIT,LAT,SOS1
Protein Size: 217 - Molecular Weight
- 25 kDa
- Gene ID
- 10750
- NCBI Accession
- NM_006613, NP_006604
- UniProt
- Q13588
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