Heart and Neural Crest Derivatives Expressed 2 (HAND2) (C-Term) Peptide
HAND2
Reactivity: Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN977846
Quick Overview for Heart and Neural Crest Derivatives Expressed 2 (HAND2) (C-Term) Peptide (ABIN977846)
Target
HAND2
(Heart and Neural Crest Derivatives Expressed 2 (HAND2))
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- DQNGEAEAFK AEIKKTDVKE EKRKKELNEI LKSTVSSNDK KTKGRTGWPQ
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Hand2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))
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Background
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Hand2 is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. It is required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. It plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Hand2 is involved in the development of branchial arches, which give rise to unique structures in the head and neck.
Alias Symbols: AI225906, AI661148, Ehand2, Hed, Th2, Thing2, bHLHa26, dHAND
Protein Interaction Partner: Hand1,Twist1
Protein Size: 217 -
Molecular Weight
- 24 kDa
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Gene ID
- 15111
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NCBI Accession
- NM_010402, NP_034532
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UniProt
- Q61039
Target
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