Histidyl-tRNA Synthetase (HARS1) (N-Term) Peptide
HARS1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977854
Quick Overview for Histidyl-tRNA Synthetase (HARS1) (N-Term) Peptide (ABIN977854)
Target
HARS1/Jo-1 (HARS1)
(Histidyl-tRNA Synthetase (HARS1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- FVLKTPKGTR DYSPRQMAVR EKVFDVIIRC FKRHGAEVID TPVFELKETL
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HARS Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HARS1/Jo-1 (HARS1) (Histidyl-tRNA Synthetase (HARS1))
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Background
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Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
Alias Symbols: FLJ20491, HRS, USH3B
Protein Interaction Partner: EEF1B2,EEF1G,EEF1B2,EEF1G,RPL5,TARS,EEF1B2,EEF1G
Protein Size: 509 -
Molecular Weight
- 56 kDa
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Gene ID
- 3035
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NCBI Accession
- NM_002109, NP_002100
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UniProt
- P12081
Target
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