HCLS1 Associated Protein X-1 (HAX1) (Middle Region) Peptide
HAX1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all HAX1 products
- HAX1 (HCLS1 Associated Protein X-1 (HAX1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HAX1 antibody (Catalog #: ARP52141_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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HCLS1 Associated Protein X-1 (HAX1) peptide
HAX1 Reactivity: Human Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HAX1 (HCLS1 Associated Protein X-1 (HAX1))
- Background
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HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HCLSBP1, HS1BP1, SCN3
Protein Interaction Partner: HCLS1,IL1A,IQGAP2,ABCB1,ABCB11,ABCB4,CTTN,DGKD,EIF3F,HCLS1,IL1A,KIAA0513,PKD2,YWHAQ,DGKD,EIF3F,IL1A
Protein Size: 279 - Molecular Weight
- 31 kDa
- Gene ID
- 10456
- NCBI Accession
- NM_006118, NP_006109
- UniProt
- O00165
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