Histone Deacetylase 4 (HDAC4) (N-Term) Peptide
HDAC4
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977906
$160.46
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100 μg
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Quick Overview for Histone Deacetylase 4 (HDAC4) (N-Term) Peptide (ABIN977906)
Target
HDAC4
(Histone Deacetylase 4 (HDAC4))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HDAC4 antibody (Catalog #: ARP34229_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HDAC4 (Histone Deacetylase 4 (HDAC4))
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Background
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC4 belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HA6116, HD4, HDAC-A, HDACA, KIAA0288, AHO3, BDMR, HDAC-4
Protein Interaction Partner: RUVBL2,TNFSF10,ANKRA2,ANKRD11,ATRX,BCL6,BCOR,BRMS1,CAMK4,CBX5,CIITA,GCM1,HDAC3,HDAC4,HDAC9,MAP1S,MAPK1,MAPK3,MECOM,MEF2A,MEF2C,MEF2D,MEGF10,NACC1,NCOR2,NFKB2,NR2C1,RANBP2,RBBP4,RFXANK,RUNX2,RUNX3,RUVBL2,SUMO1,SUMO2,TNFRSF14,YWHAE,YWHAG,YWHAZ,ZBTB16,AR,ATF2,BCL6,BCOR,CBX5,CTBP1,Ctbp1,DNAJB6,DNAJB8,FOXP3,GATA1,HDAC3,HDAC4,HDAC9,IKZF1,IKZF2,IKZF3,IKZF4,MAPK1,MAPK3,MECOM,MEF2A,MEF2C,MEF2D,MORC2,NCOR1,NCOR2,NR2C1,NR2C2,Ncor2,PPARD,PPARG,RARA,RBBP4,RUNX2,RXRA,SENP1,SFN,SUMO2,SUV39H1,UBE2I,YWHAB,YWHAE,YWHAG,YWHAZ,ZBTB16,ZNF354A
Protein Size: 1084 -
Molecular Weight
- 119 kDa
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Gene ID
- 9759
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NCBI Accession
- NM_006037, NP_006028
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UniProt
- P56524
Target
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