Histone Deacetylase 9 (HDAC9) (Middle Region) Peptide
HDAC9
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all HDAC9 products
- HDAC9 (Histone Deacetylase 9 (HDAC9))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HDAC9 antibody (Catalog #: ARP42793_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HDAC9 (Histone Deacetylase 9 (HDAC9))
- Background
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC9 has sequence homology to members of the histone deacetylase family. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. HDAC9 may play a role in hematopoiesis. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
Alias Symbols: DKFZp779K1053, HD7, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, KIAA0744, MITR, HD9, HD7b
Protein Interaction Partner: BCL6,CBX5,CTBP1,ETV6,HDAC1,HDAC3,HDAC4,MEF2A,NCOR1,SIN3A,SIN3B,SUMO1,SUMO2,ZBTB16,CBX5,CTBP1,ETV6,FOXP3,HDAC1,HDAC1,HDAC3,HDAC3,HDAC4,HEY2,HIST2H3A,HIST4H4,MEF2A,MORF4L2,NCOR1,NRIP1,SIN3A,SIN3B,SUV39H1
Protein Size: 590 - Molecular Weight
- 66 kDa
- Gene ID
- 9734
- NCBI Accession
- NM_014707, NP_055522
- UniProt
- A7E2F3
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