Hexosaminidase A (HEXA) (C-Term) Peptide
HEXA
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN977949
Quick Overview for Hexosaminidase A (HEXA) (C-Term) Peptide (ABIN977949)
Target
Hexosaminidase A (HEXA)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- WKDFYIVEPL AFEGTPEQKA LVIGGEACMW GEYVDNTNLV PRLWPRAGAV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HEXA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Hexosaminidase A (HEXA)
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Background
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This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).
Alias Symbols: MGC99608, TSD
Protein Interaction Partner: GM2A,GM2A,USP22
Protein Size: 529 -
Molecular Weight
- 48 kDa
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Gene ID
- 3073
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NCBI Accession
- NM_000520, NP_000511
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UniProt
- P06865
Target
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