Histone Cluster 1, H3a (HIST1H3A) (N-Term) Peptide
HIST1H3A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN978007
Quick Overview for Histone Cluster 1, H3a (HIST1H3A) (N-Term) Peptide (ABIN978007)
Target
HIST1H3A
(Histone Cluster 1, H3a (HIST1H3A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- KQTARKSTGG KAPRKQLATK AARKSAPATG GVKKPHRYRP GTVALREIRR
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HIST1H3A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HIST1H3A (Histone Cluster 1, H3a (HIST1H3A))
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Background
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Alias Symbols: H3/A, H3FA, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J
Protein Interaction Partner: AURKB,CBX1,RAD51L1,SETDB1,SUV39H1,UHRF1,ALL1,ANP32A,ASF1A,ASF1B,ASH1L,ASH2L,AT3G49660,ATRX,AURKB,BAZ1B,BPTF,CALCOCO1,CARM1,CBX1,CBX3,CBX5,CBX7,CDYL,CHAF1A,CHAF1B,CHD1,CHD3,CREBBP,CTCFL,CUL4A,DDB1,DEK,DNMT3A,DYRK1A,EED,EGLN1,EHMT1,EHMT2,EID1,EP300,ERCC6,EZ
Protein Size: 136 -
Molecular Weight
- 15 kDa
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Gene ID
- 8350
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NCBI Accession
- NM_003529, NP_003520
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UniProt
- P68431
Target
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