Hepatocyte Nuclear Factor 4, alpha (HNF4A) (N-Term) Peptide
HNF4A
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all HNF4A products
- HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HNF4A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Hepatocyte Nuclear Factor 4, alpha (HNF4A) peptide
HNF4A Reactivity: Human, Pig, Dog Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))
- Background
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The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
Alias Symbols: HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14
Protein Interaction Partner: CREBBP,ELP3,H3F3A,SMARCA4,COPS5,CREBBP,ESR1,FOXO1,HNF1A,HNF4A,MAPK14,MECR,MED1,MED14,NCOA1,NCOA2,NCOA6,NPPA,NR0B2,NR2C2,NR2F1,NRBF2,NRIP1,PNRC1,PNRC2,PPARGC1A,PPARGC1B,PRKAA2,PROX1,SIRT1,SMAD2,SMAD3,SMAD4,SP1,SREBF2,SUB1,TP53,TRIM24,UBE2I,ZNHIT3,AR,COPS5,CREBBP,CTNNB1,EXT2,FOXO1,GPS2,HDAC3,HDAC4,HNF4A,MAPK1,MAPK3,MED1,MED10,MED14,MED16,MED17,MED21,MED23,MED24,MED7,NCOA1,NCOA2,NCOA6,NCOR2,NPPA,NR0B2,NR1I3,NR2C2,NRIP1,PABPC4,PCBD1,PNRC1,PNRC2,PPARGC1A,PPARGC1B,PRMT1,PROX1,RAD50,SIRT1,SMAD3,SMAD4,SNCG,SP1,SREBF1,SREBF2,STK16,SUB1,TGS1,TP53,UBE2I,VDR,XPO1,ZNHIT3
Protein Size: 474 - Molecular Weight
- 53 kDa
- Gene ID
- 3172
- NCBI Accession
- NM_000457, NP_000448
- UniProt
- P41235
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