Hepatocyte Nuclear Factor 4, alpha (HNF4A) (Middle Region) Peptide
HNF4A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN978084
$160.46
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100 μg
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Quick Overview for Hepatocyte Nuclear Factor 4, alpha (HNF4A) (Middle Region) Peptide (ABIN978084)
Target
HNF4A
(Hepatocyte Nuclear Factor 4, alpha (HNF4A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HNF4A antibody (Catalog #: ARP45595_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Hepatocyte Nuclear Factor 4, alpha (HNF4A) peptide
HNF4A Reactivity: Human, Pig, Dog Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))
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Background
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The protein encoded by HNF4A is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.
Alias Symbols: FLJ39654, HNF4, HNF4a7, HNF4a8, HNF4a9, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14, HNF4alpha
Protein Interaction Partner: CREBBP,ELP3,H3F3A,SMARCA4,COPS5,CREBBP,ESR1,FOXO1,HNF1A,HNF4A,MAPK14,MECR,MED1,MED14,NCOA1,NCOA2,NCOA6,NPPA,NR0B2,NR2C2,NR2F1,NRBF2,NRIP1,PNRC1,PNRC2,PPARGC1A,PPARGC1B,PRKAA2,PROX1,SIRT1,SMAD2,SMAD3,SMAD4,SP1,SREBF2,SUB1,TP53,TRIM24,UBE2I,ZNHIT3,AR,CREBBP,CTNNB1,EXT2,FOXO1,MED1,MED10,MED14,MED16,MED17,MED21,MED23,MED24,MED7,NCOA1,NCOA2,NR0B2,NR2C2,PABPC4,PPARGC1B,RAD50,SNCG,STK16,SUB1,TP53,ZNHIT3
Protein Size: 442 -
Molecular Weight
- 49 kDa
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Gene ID
- 3172
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NCBI Accession
- NM_001030003, NP_001025174
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UniProt
- P41235
Target
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