Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) Peptide
HNRNPA1
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN978097
Quick Overview for Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1) Peptide (ABIN978097)
Target
HNRNPA1
(Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HNRPA1 antibody (Catalog #: ARP40383_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))
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Background
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HNRPA1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). HNRPA1 has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. HNRPA1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.
Alias Symbols: HNRPA1, HNRPA1L3, hnRNP A1, hnRNP-A1
Protein Interaction Partner: BAT2,BAT5,FEN1,NFKBIA,PABPN1,PHYHIP,PRMT1,RPL21,SAFB,SFRS12,SUFU,TNPO1,TTF2,XRN1,ARHGAP23,ARID2,BAT2,CAPN2,CCNT1,CDK9,CENPC1,DDX17,DDX5,FEN1,FRMD4A,GTF2A1,GTF2E2,HNRNPA1,HNRNPA2B1,HNRNPAB,HNRNPC,HNRNPH1,HNRNPK,HNRNPL,HNRNPM,HNRNPR,HNRNPUL2,HNRPDL,HSP90AB1,HSPA2,HSPA9,IGF2BP1,IGF2BP2,IGF2BP3,ILF2,ILF3,KHDRBS2,KHSRP,KIAA0368,LARP7,LOC341333,LOC440563,MEPCE,MOV10,MRPL37,MRPS27,NFKBIA,NNT,PABPC1,PABPC4,PLOD2,PLOD3,PRKCZ,PRMT1,PRMT8,PTMA,PURA,RBM39,RBMX,ROCK1,RPAP1,RRP1B,Rrp1b,SAFB,SRP72,SYNCRIP,SYTL2,TARDBP,UBR1,UBR2,YTHDF2,ZFR
Protein Size: 320 -
Molecular Weight
- 35 kDa
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Gene ID
- 3178
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NCBI Accession
- NM_002136, NP_002127
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UniProt
- Q6IPF2
Target
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