Heat Shock 22kDa Protein 8 (HSPB8) (Middle Region) Peptide
HSPB8
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN978319
Quick Overview for Heat Shock 22kDa Protein 8 (HSPB8) (Middle Region) Peptide (ABIN978319)
Target
HSPB8
(Heat Shock 22kDa Protein 8 (HSPB8))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- PEELMVKTKD GYVEVSGKHE EKQQEGGIVS KNFTKKIQLP AEVDPVTVFA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HSPB8 Antibody(ARP55036_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))
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Background
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HSPB8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of HSPB8 protein is induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, HSPB8 appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in the encoding HSPB8 gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
Alias Symbols: CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22
Protein Interaction Partner: HSPB1,HSPB8,BAG3,CSNK2A1,HSPB1,HSPB6,HSPB7,HSPB8,MAPK3,PRKCA,BAG3,HSPB1,HSPB2,HSPB7,HSPB8
Protein Size: 196 -
Molecular Weight
- 21 kDa
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Gene ID
- 26353
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NCBI Accession
- NM_014365, NP_055180
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UniProt
- Q9UJY1
Target
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