Inhibitor of Growth Family, Member 3 (ING3) (N-Term) Peptide
ING3
Reactivity: Human, Mouse
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN978549
Quick Overview for Inhibitor of Growth Family, Member 3 (ING3) (N-Term) Peptide (ABIN978549)
Target
ING3
(Inhibitor of Growth Family, Member 3 (ING3))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ING3 antibody (Catalog #: ARP33346_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ING3 (Inhibitor of Growth Family, Member 3 (ING3))
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Background
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ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Alias Symbols: Eaf4, FLJ20089, ING2, p47ING3, MEAF4
Protein Interaction Partner: NR1H2,NR1H3,ACTL6A,BRD8,DMAP1,EPC1,EPC2,HHT1,HHT2,KAT5,MEAF6,MORF4L1,RUVBL1,RUVBL2,TRRAP,YEATS4
Protein Size: 418 -
Molecular Weight
- 47 kDa
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Gene ID
- 54556
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NCBI Accession
- NM_019071, NP_061944
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UniProt
- Q9NXR8
Target
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