Inhibin, beta A (INHBA) (N-Term) Peptide
INHBA
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN978554
Quick Overview for Inhibin, beta A (INHBA) (N-Term) Peptide (ABIN978554)
Target
INHBA
(Inhibin, beta A (INHBA))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- CPSCALAALP KDVPNSQPEM VEAVKKHILN MLHLKKRPDV TQPVPKAALL
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-INHBA Antibody(ARP54663_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- INHBA (Inhibin, beta A (INHBA))
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Background
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The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Alias Symbols: EDF, FRP
Protein Interaction Partner: INHBA,ACVR1,ACVR1B,ACVR2A,ACVR2B,CHRDL2,ENG,FST,FSTL3,IGFBP7,INHA,INHBA,INHBB,INHBC,TGFBR3,ACVR1B,ACVR2A,ACVR2B,CHRDL2
Protein Size: 426 -
Molecular Weight
- 44 kDa
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Gene ID
- 3624
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NCBI Accession
- NM_002192, NP_002183
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UniProt
- P08476
Target
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