Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) Peptide
KCNN3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN978827
Quick Overview for Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) Peptide (ABIN978827)
Target
KCNN3
(Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-KCNN3 antibody (Catalog #: ARP35441_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))
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Background
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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN3 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN3 contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions.
Alias Symbols: SK3, hSK3, SKCA3, KCa2.3
Protein Size: 426 -
Molecular Weight
- 47 kDa
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Gene ID
- 3782
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NCBI Accession
- NM_170782, NP_740752
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UniProt
- Q8WXG7
Target
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