Karyopherin alpha 1 (Importin alpha 5) (KPNA1) Peptide
KPNA1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN979098
Quick Overview for Karyopherin alpha 1 (Importin alpha 5) (KPNA1) Peptide (ABIN979098)
Target
KPNA1
(Karyopherin alpha 1 (Importin alpha 5) (KPNA1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-KPNA1 antibody (Catalog #: ARP54670_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))
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Background
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Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. KPNA1 interacts with RAG1 and may play a role in V(D)J recombination.Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IPOA5, NPI-1, RCH2, SRP1
Protein Interaction Partner: ANP32A,ELAVL1,HIST2H2BE,HIST3H3,LEF1,LMO4,PAX5,RAG1,RUNX1T1,SRP19,STAT1,STAT3,TAF9,UBR5,BTBD12,CSE1L,KPNB1,LYAR,MEPCE,NUP54,NUP62,RAG1,RAG2,RANBP2,RUNX1T1,STAT1,UBR5,USP1
Protein Size: 538 -
Molecular Weight
- 60 kDa
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Gene ID
- 3836
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NCBI Accession
- NM_002264, NP_002255
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UniProt
- P52294
Target
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