Ligase IV, DNA, ATP-Dependent (LIG4) Peptide
LIG4
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all LIG4 products
- LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-LIG4 antibody (Catalog #: ARP34122_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
- Background
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LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.
Protein Interaction Partner: XRCC4,APLF,NHEJ1,PRKDC,SMC2,XRCC4,ATM,ATR,NHEJ1,PNKP,PRKDC,XRCC4
Protein Size: 911 - Molecular Weight
- 104 kDa
- Gene ID
- 3981
- NCBI Accession
- NM_002312, NP_002303
- UniProt
- Q8IY66
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