V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (N-Term) Peptide
LYN
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN979668
Quick Overview for V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (N-Term) Peptide (ABIN979668)
Target
LYN
(V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- DPTSNKQQRP VPESQLLPGQ RFQTKDPEEQ GDIVVALYPY DGIHPDDLSF
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-LYN Antibody(ARP54696_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) peptide
LYN Reactivity: Human, Cow Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))
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Background
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LYN down regulates expression of stem cell growth factor receptor (KIT).LYN acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation.LYN acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents.LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.
Alias Symbols: FLJ26625, JTK8, p53Lyn, p56Lyn
Protein Interaction Partner: KIT,HCVgp1,KIT,LYN,PDE4D,RGS16,UBB,ACTB,ADAM15,BANK1,BCAR1,BTK,CASP3,CASP7,CASP9,CBL,CBLC,CD19,CD22,CD24,CD36,CD79A,CD79B,CDK1,CDK2,CDKN1B,CHST15,CRKL,CSF1R,CSF2RA,CSF2RB,CSF3R,CSK,CSNK2B,CTLA4,DAPP1,DLG4,DOK1,DOK2,DOK3,EGFR,EPOR,EVL,FCAR,FCER1G,FCGR2A,FC
Protein Size: 512 -
Molecular Weight
- 58 kDa
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Gene ID
- 4067
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NCBI Accession
- NM_002350, NP_002341
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UniProt
- P07948
Target
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